Access to taxol analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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Details

544335, 546147, 546165, 548454, 548525, 549 23, 549 57, 549 60, C07D23910, C07D21724, C07D41106, C07D33318

Patent

active

057506914

ABSTRACT:
Transformations of taxol, baccatin III and of 10-deacetyl baccatin III provide access to novel taxol analogs and key intermediates thereto.

REFERENCES:
patent: 5274124 (1993-12-01), Holton
Nicolaou, et al., "Convergent Strategy Towards Taxol. A Facile Enantioselective Entry Into A Fully Functionalized Ring A System", J. Chem. Soc., Chem. Commun.,, 1117-1118 (1992).
Nicolaou, et al., "Synthesis of a Fully Functionalized CD Ring System of Taxol", J. Chem. Soc., Chem. Commun., 1118-1119 (1992).
Nicolaou, et al., "Synthesis of ABC Taxoid Ring Systems via a Convergent Strategy", J. Chem. Soc., Chem. Commun., 1024-1026 (1993).
Nicolaou, et al., "Design, Synthesis and Biological Activity of Protaxols", Nature, 364: 464-467 (1993).
Ojima, et al., "New and Effective Approaches to the Semisynthesis of Taxol and its C-13 Side Chain Analogs by Means of B-Lactam Synthon Method", Tetrahedron, 48: 6985-7012 (1992).
Ojima, et al., "A Highly Efficient Route to Taxotere by the B-Lactam Synthon Method", Tet. Letters, 34: 4149-4152 (1993).
Holton, R., "Method for Preparation of Taxol", Chem. Abstracts, 114: 164568q (1990).
Griffith, et al., "TPAP: Tetra-n-propylammonium Perruthenate, A Mild and Convenient Oxidant for Alcohols", Aldrichimica Acta, 23: 13-19 (1990).

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