Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1995-08-07
1998-05-12
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544335, 546147, 546165, 548454, 548525, 549 23, 549 57, 549 60, C07D23910, C07D21724, C07D41106, C07D33318
Patent
active
057506914
ABSTRACT:
Transformations of taxol, baccatin III and of 10-deacetyl baccatin III provide access to novel taxol analogs and key intermediates thereto.
REFERENCES:
patent: 5274124 (1993-12-01), Holton
Nicolaou, et al., "Convergent Strategy Towards Taxol. A Facile Enantioselective Entry Into A Fully Functionalized Ring A System", J. Chem. Soc., Chem. Commun.,, 1117-1118 (1992).
Nicolaou, et al., "Synthesis of a Fully Functionalized CD Ring System of Taxol", J. Chem. Soc., Chem. Commun., 1118-1119 (1992).
Nicolaou, et al., "Synthesis of ABC Taxoid Ring Systems via a Convergent Strategy", J. Chem. Soc., Chem. Commun., 1024-1026 (1993).
Nicolaou, et al., "Design, Synthesis and Biological Activity of Protaxols", Nature, 364: 464-467 (1993).
Ojima, et al., "New and Effective Approaches to the Semisynthesis of Taxol and its C-13 Side Chain Analogs by Means of B-Lactam Synthon Method", Tetrahedron, 48: 6985-7012 (1992).
Ojima, et al., "A Highly Efficient Route to Taxotere by the B-Lactam Synthon Method", Tet. Letters, 34: 4149-4152 (1993).
Holton, R., "Method for Preparation of Taxol", Chem. Abstracts, 114: 164568q (1990).
Griffith, et al., "TPAP: Tetra-n-propylammonium Perruthenate, A Mild and Convenient Oxidant for Alcohols", Aldrichimica Acta, 23: 13-19 (1990).
Guy Rodney K.
Nantermet Philippe G.
Nicolaou K. C.
Ueno Hiroaki
Lewis Donald G.
Richter Johann
Sackey Ebenezer
The Scripps Research Institute
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