Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1992-06-29
1997-04-15
Kight, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435 4, 435 71, 435 723, 436 63, 436 64, 436811, 436813, 436804, 436504, 436518, 536 111, 536 41, 536117, 53612313, 536124, 536 551, 514 8, C12Q 148, C12Q 100, G01N 3348, A61K 3816
Patent
active
056208642
ABSTRACT:
A biologically active oligosaccharide compound comprising at least two L hexose rings connected together by an ether oxygen atom. The ether oxygen atom is connected to a first of the rings at the first carbon atom to the right of the hexose ring oxygen atom. The compound contains at least one sulfate or phosphate group connected to the first ring at the third carbon atom to the right of the ring oxygen or to a methyl group at the fifth carbon atom to the right of the ring oxygen atom.
The invention further includes the method for using the above oligosaccharide compound to detect .alpha. 1,3-L-fucosyltransferases or to block the activity of such .alpha. 1,3-L-fucosyltransferases or structures which mimic the structure of such fucosyltransferases to the extent that such structures bind to compounds of the present invention, e.g., as in the case of HIV virus.
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Chandrasekaran E. V.
Jain Rakesh K.
Matta Khushi L.
Dunn Michael L.
Health Research , Inc.
Kight John
Leary Louise N.
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