Accellular synthesis of cephalosporins

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-5-aza-bicyclo

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435926, C12D 900

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active

041782100

ABSTRACT:
A cephalosporin antibiotic is produced from a precursor comprising the five membered thiazolidine ring and the .beta. lactam moiety characteristics of penicillins by contacting the precursor with a cell-free extract of Cephalosporium acremonium in the presence of ATP under conditions favoring high oxygen transfer. Preferably, an ATP regeneration system comprising a phosphate donor and a phosphotransferase enzyme is included in the reaction.

REFERENCES:
patent: 3825473 (1974-07-01), Gargiuolo
E. P. Abraham, Biosynthesis and Enzymatic Hydrolysis of Penicillins and Cephalosporins, University of Tokyo Press, pp. 12-17.
S. W. Drew et al., The Obligatory Role of Methionine in the Conversion of Sulfate to Cephalosporin C, European Journal of Applied Microbiology, 2, 1975, pp. 121-128.
A. Demain, Biochemistry of Penicillin and Cephalosporin Fermentations, Lloydia, vol. 37, No. 2 (1974).
Morin et al., Chemistry of Cephalosporin Antiobiotics III, Chemical Correlation of Penicillin and Cephalosporin Antibiotics, J. Amer. Chem. Soc., 85, (1963), pp. 1896-1897.
Patricia Fawcett et al., Aspects of Cephalosporins and Penicillin Biosynthesis, Academic Press, pp. 129-138.
Brenda Smith et al., Biosynthesis of Penicillin and Cephalosporin C, Biochem. J. 103, pp. 877-890 (1967).
Kitano et al., Agr. Biol. Chem., 38(9), pp. 1761-1762, 1974.

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