Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
530399, A61K 3818
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
Igarashi, et al., Regulation of Connective Tissue Growth Factor Gene Expression in Human Skin Fibroblast and Durng Would Repair, Molecular Biology of the Cell, vol. 4:637-645, Jun. 1993.
Ryseck, et al., Structure, Mapping, and Expression of fisp-12 a Growth Factor-inducible Gene Encoding a Secreted Cysteine-rich Protein, Cell Growth & Differentiation, vol. 2:225-233, May 1991.
Bradham, Jr. Douglass M.
Grotendorst Gary R.
University of South Florida
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