Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1998-09-24
2000-08-22
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530399, 604 20, 607 88, 607 89, A61N 130
Patent
active
061074667
ABSTRACT:
Disclosed is a method for accelerating wound healing in a mammal. The method includes identifying an unhealed wound site or partially-healed wound site in a mammal; administering a photosensitizer to the mammal; waiting for a time period wherein the photosensitizer reaches an effective tissue concentration at the wound site; and photoactivating the photosensitizer at the wound site. The dose of photodynamic therapy is selected to stimulate the production of one or more growth factor by cells at the wound site, without causing tissue destruction.
REFERENCES:
patent: 5368841 (1994-11-01), Trauner et al.
patent: 5405369 (1995-04-01), Selman et al.
Arm etal., "Effect of Controlled Release of Platelet-derived Growth Factor From a Porous Hydroxyapatite Implant on Bone Ingrowth", Biomaterials 17:703-709, 1996.
Bachor et al., "Mechanism of Photosensitization by Microsphere-bound Chlorin e.sub.6 in Human Bladder Carcinoma Cells", Cancer Research 51:4410-4414, 1991.
Bachor et al., "Photosensitized Destruction of Human Bladder Carcinoma Cells Treated with Chlorin e.sub.6 -Conjugated Microspheres", Proc. Natl. Acad. Sci. USA 88:1580-1584, 1991.
Batlle, "Porphyrins, Poprhyrias, Cancer and Photodynamic Therapy -A Model for Carcinogenesis", J. Photochem. Photobiol. B: Biol. 20:5-22, 1993.
Beck et al., "One Systemic Administration of Transforming Growth Factor-.beta.1 Reverses Age-- or Glucocorticoid-impaired Wound Healing", J. Clin. Invest. 92:2841-2849, 1993.
Beems et al., "Photosensitizing Properties of Bacteriochlorophyllin .alpha.and Bacteriochlorin .alpha., Two Derivatives of Bacteriochlorophyll .alpha.", Photochemistry and Photobiology 46:639-643, 1987.
Bennett et al., "Growth Factors and Wound Healing: Biochemical Properties of Growth Factors and Their Receptors", The American Journal of Surgery 165:728-737, 1993.
Brown et al., "Acceleration of Tensile Strength of Incisions Treated with EGF and TGF-.beta.", Ann. Surg. 208:788-794, 1988.
Cox, "Transforming Growth Factor-Beta 3", Cell Biology International 19:357-371, 1995.
Davies et al., "In Vitro Assessment of the Biological Activity of Basic Fibroblast Growth Factor Released from Various Polymers and Biomatrices", Journal of Biomaterials Applications 12:31-56, 1997.
Detmar et al., "Keratinocyte-Derived Vascular Permeability Factor (Vascular Endothelial Growth Factor) is A Potent Mitogen for Dermal Microvascular Endothelial Cells", J. Investigative Dermatology 105:44-50, 1995.
Dougherty et al., Photodynamic Therapy of Neoplastic Disease, vol. 1, pp. 1-19, CRC Press, (Kessel, ed.) Boca Raton, 1989.
Evans et al., "Effect of Photodynamic Therapy on Tumor Necrosis Factor Production by Murine Macrophages", Journal of the National Cancer Institute 82:34-39, 1990.
Frank et al., "Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes", The Journal of Biological Chemistry 270: 12607-12613, 1995.
Fukunaga et al., "Aluminium .beta.-Cyclodextrin Sulphate as a Stabilizer and Sustained-release Carrier for Basic Fibroblast Growth Factor", J. Pharm. Pharmacol. 46:168-171, 1994.
Greenhalgh, "The Role of Growth Factors in Wound Healing", The Journal of Trauma: Injury, Infection, and Critical Care 41:159-167, 1996.
Gurinovich et al., "Photodynamic Activity of Chlorin e.sub.6 and Chlorin e.sub.6 Ethylenediamide In Vitro and In Vivo", J. Photochem. Photobiol. B: Biol. 13:51-57, 1992.
Hamblin et al., "Photosensitizer Targeting in Photodynamic Therapy I. Conjugates of Haematoporphyrin With Albumin and Transferrin", Journal of Photochemistry and Photobiology B: Biology 26:45-56, 1994.
Hamblin et al., "Photosensitizer Targeting in Photodynamic Therapy II. Conjugates of Haematoporphyrin With Serum Lipoproteins", Journal of Photochemistry and Photobiology B: Biology 26: 147-157, 1994.
Hill et al., "The Effect of PDGF on the Healing of Full Thickness Wounds in Hairless Guinea Pigs", Comp. Biochem. Physiol. 100A:365-370, 1991.
Kamler et al., "Impact of Ischemia in Tissue Oxygenation and Wound Healing: Improvement By Vasoactive Medication", Adv. Exp. Med. Biol. 316:419-424, 1992.
Kessel, "Determinants of Photosensitization by Purpurins", Photochemistry and Photobiology 50:169-174, 1989.
Kessel, "Interactions Between Porphyrins and Mitochondrial Benzodiazepine Receptors", Cancer Letters 39:193-198, 1988.
Kessel et al., "Photosensitization with Derivatives of Chlorophyll", Photochem. & Photobiology 49:157-160, 1989.
Kiecolt-Glaser et al., "Slowing of Wound Healing by Psychological Stress", Lancet 346:1194-196, 1995.
Koren et al., "Photodynamic Therapy-An Alternative Pathway in the Treatment of Recurrent Breast Cancer", Int. J. Radiation Oncology Biol. Phys. 28:463-466, 1993.
Kreimer-Birnbaum, "Modified Porphyrins, Chlorins, Phthalocyanines, and Purpurins: Second-Generation Photosensitizers for Photodynamic Therapy", Seminars in Hematology 26:157-173, 1989.
Kusstatscher et al., "Different Molecular Forms of Basic Fibroblast Growth Factor (bfGF) Accelerate Duodenal Ulcer Healing in Rats", The Journal of Pharmacology and Experimental Therapeutics 275:456-461, 1995.
Molpus et al., "Intraperitoneal Photodynamic Therapy of Human Epithelial Ovarian Carcinomatosis in a Xenograft Murine Model", Cancer Research 56:1075-1082, 1996.
Morgan et al., "Metallopurpurins and Light: Effect on Transplantable Rat Bladder Tumors and Murine Skin", Photochemistry and Photobiology 51:589-592, 1990.
Nicoll et al., "In Vitro Release Kinetics of Biologically Active Transforming Growth Factor-.beta.1 from a Novel Porous Glass Carrier", Biomaterials 18:853-859, 1997.
Obochi et al., "Photodynamic Therapy (PDT) as a Biological Modifier", SPIE 2675:122-131, 1996.
Puolakkainen et al., "The Enhancement in Wound Healing by Transforming Growth Factor-.beta..sub.1 (TGB-B.sub.1) Depends on the Topical Delivery System", Journal of Surgical Research 58:321-329, 1995.
Reed et al., "Wound Repair in Older Patients: Preventing Problems and Managing the Healing", Geriatrics 53:88-94, 1998.
Rosenberg, "Wound Healing in the Patient with Diabetes Mellitus", Nursing Clinics of North America 25:247-261, 1990.
Suh et al., "Insulin-Like Growth Factor-I Reverses the Impairment of Wound Healing Induced by Corticosteroids in Rats", Endocrinology 131:2399-2403, 1992.
Uthoff et al., "Thalidomide as Replacement for Steroids in Immunosuppression After Lung Transplantation", Ann. Thorac. Surg. 59:277-282, 1995.
Yamamoto et al., "Activation of Mouse Macrophages by In Vivo and In Vitro Treatment With a Cyanine Dye, Lumin", J. Photochem. Photobiol. B: Biol. 13:295-306, 1992.
Yamamoto et al., "Effectiveness of Photofrin II in Activation of Macrophages and In Vitro Killing of Retinoblastoma Cells", Photochemistry and Photobiology 60:160-164, 1994.
Young, "Nutritional Problems in Critical Care Malnutrition and Wound Healing", Heart & Lung 17:60-67, 1988.
Hamblin Michael R.
Hasan Tayyaba
Trauner Kenneth
Delaney Patrick R.
The General Hospital Corporation
Tsang Cecilia J.
LandOfFree
Acceleration of wound healing by photodynamic therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acceleration of wound healing by photodynamic therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acceleration of wound healing by photodynamic therapy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-582535