Acceleration of nucleic acid hybridization

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 681, 435 701, 435820, 436501, 536 27, 530358, 935 9, 935 19, 935 34, 935 78, C12Q 168, C07H 2100, C07K 1518

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050155695

ABSTRACT:
This invention relates to an improvement in nucleic acid hybridization technology. Nucleic acids bind to complementary partners in a predictable manner such that the detection of complementary partners is possible. The acceleration of the binding process is desired objective and will find broad application in a variety of industrial, medical, and research uses. In particular this invention relates to the acceleration of nucleic acid hybridization by heterogeneous nuclear ribonucleoproteins [hnRNPs].

REFERENCES:
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Cobianchi, F. et al., "Mammalian Heterogeneous Nuclear Ribonucleoprotein Complex Protein A1", The Journal of Biological Chemistry, vol. 263, No. 2, Issue of Jan. 15, pp. 1063-1071 (1988).
Merrill, B. M. et al., "Phenylalanines That Are Conserved Among Several RNA-Binding Proteins Form Part of a Nucleic Acid-Binding Pocket in the A1 Heterogeneous Nuclear Ribonucleoprotein", The Journal of Biological Chemistry, vol. 263, No. 7, Issue of Mar. 5, pp. 3307-3313 (1988).

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