Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1990-06-26
1992-04-21
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514561, 514562, 514565, 514566, 514585, 514586, 514587, 514597, 514598, 560 18, 560 21, 560 34, 562435, 562437, 562438, 562439, 564 48, 564 50, 564 52, 564 53, 564 54, 564 27, 564 28, 564 29, 546337, A61K 3117
Patent
active
051068737
ABSTRACT:
This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds contain two urea or thiourea, amide, or amine moieties or combinations of said moieties and have the following general formula: ##STR1## wherein m and n are zero or one, W and YNH and ##STR2## form the urea, thiourea, amide or amine moieties; and R.sub.1 and R .sub.2 are hydrogen or a hydrocarbon radical.
REFERENCES:
patent: 2762842 (1956-09-01), Hafliger et al.
patent: 4224242 (1980-09-01), Sulkowski et al.
patent: 4397868 (1983-08-01), DeVries
patent: 4437880 (1984-03-01), Takahashi et al.
patent: 4473579 (1984-09-01), DeVries et al.
O'Brien Patrick M.
Sliskovic Drago R.
Wilson Michael W.
Kumar S.
Newtson Ruth H.
Robinson Allen J.
Warner-Lambert & Company
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