Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Reexamination Certificate
2006-02-07
2006-02-07
Jones, Dameron L. (Department: 1618)
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
C534S007000, C424S001110, C424S001650, C424S009100
Reexamination Certificate
active
06995247
ABSTRACT:
The present invention provides an α-particle-emitting radioisotope chelation complex comprising225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N′,N′,N′,N′-hexaacetic acid (HEHA) (225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional225Ac-HEHA. The bifunctional HEHA and the bifunctional225Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof. Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from225Ac, a method of decontaminating a person who has been externally contaminated with225Ac, and a method of detoxifying a person who has internalized225Ac.
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Brechbiel Martin W.
Deal Kim
Jones Dameron L.
Leydig , Voit & Mayer, Ltd.
The United States of America as represented by the Department of
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