Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2008-07-15
2008-07-15
Channavajjala, Lakshmi S. (Department: 1611)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S464000, C424S451000, C424S502000
Reexamination Certificate
active
07399488
ABSTRACT:
An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
REFERENCES:
patent: 3773955 (1973-11-01), Pachter
patent: 3966940 (1976-06-01), Pachter et al.
patent: 3980766 (1976-09-01), Shaw et al.
patent: 4070494 (1978-01-01), Hoffmeister et al.
patent: 4457933 (1984-07-01), Gordon et al.
patent: 5508042 (1996-04-01), Oshlack et al.
patent: 5756483 (1998-05-01), Merkus
patent: 5849240 (1998-12-01), Miller et al.
patent: 5891471 (1999-04-01), Miller et al.
patent: 5952005 (1999-09-01), Olsson et al.
patent: 5958452 (1999-09-01), Oshlack et al.
patent: 5965161 (1999-10-01), Oshlack et al.
patent: 5965163 (1999-10-01), Miller et al.
patent: 5968551 (1999-10-01), Oshlack et al.
patent: 6048736 (2000-04-01), Kosak
patent: 6068855 (2000-05-01), Leslie et al.
patent: 6103261 (2000-08-01), Chasin et al.
patent: 6162467 (2000-12-01), Miller et al.
patent: 6261599 (2001-07-01), Oshlack et al.
patent: 6277384 (2001-08-01), Kaiko et al.
patent: 6294195 (2001-09-01), Oshlack et al.
patent: 6309668 (2001-10-01), Bastin et al.
patent: 6310072 (2001-10-01), Smith et al.
patent: 6335033 (2002-01-01), Oshlack et al.
patent: 6375957 (2002-04-01), Kaiko et al.
patent: 6475494 (2002-11-01), Kaiko et al.
patent: 6696088 (2004-02-01), Oshlack et al.
patent: 6706281 (2004-03-01), Oshlack et al.
patent: 6723343 (2004-04-01), Kugelmann
patent: 6743442 (2004-06-01), Oshlack et al.
patent: 2002/0081333 (2002-06-01), Oshlack et al.
patent: 2006/0104909 (2006-05-01), Vaghefi et al.
Cortesi, et al., “Sugar cross-linked gelatin for controlled release: microspheres and disks,”Biomaterials19:1641-1649 (1998).
Gennaro, ed.,Remington: The Science and Practice of Pharmacology, 20thed., Lipincott: Baltimore, MD, pp. 704-706 (2000).
Buchwald Stephen L.
Fleming Alison B.
Hirsh Jane
Kibanov Alexander M.
Lo Whe Yong
Channavajjala Lakshmi S.
Collegium Pharmaceutical, Inc.
Pabst Patent Group LLP
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