Abundant extracellular products and methods for their...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C424S009100, C424S009200, C424S184100, C424S185100, C424S190100, C424S234100, C424S248100, C435S004000, C435S243000, C435S252100, C530S300000, C530S350000, C536S023100, C536S023700

Reexamination Certificate

active

07002002

ABSTRACT:
Vaccines based on one or more combinations of majorly abundant extracellular products of pathogens and methods for their use and production are presented. The most prevalent or majorly abundant extracellular products of a target pathogen are selected irrespective of their absolute molecular immunogenicity and used as vaccines to stimulate a protective immune response in mammalian hosts against subsequent infection by the target pathogen. The majorly abundant extracellular products may be characterized and distinguished by their respective N-terminal amino acid, amino acid, or DNA sequences. As the vaccines may comprise different combinations of the extracellular products, subunits thereof, or encoding nucleic acids, a broad range of effective immunotherapeutic compositions are provided by the present invention. In addition to other infectious agents, the vaccines so produced can be used to stimulate an effective immune response against intracellular pathogens and in particularMycobacterium tuberculosis.

REFERENCES:
Oettinger, T., et al “Cloning and B-cell-epitope mapping of MPT64 fromMycobaterium tuberculosisH37Rv”, Infection and Immunity, vol. 62, No. 5, pp. 2058-2064, May 1994.
Sasaki, T. et al, EMBL D47831, Direct submission “Rice cDNA from Shot” May 1, 1994.
Silvanovich, A., et al, “Nucleotide sequence analysis of three cDNAs coding for Poa p IX isoallergens of kentucky bluegrass pollen”, The Journal of Biological Chemistry, vol. 266, No. 2, pp. 1204-1210, Jan. 1991.

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