Absorption-promoting compounds, compositions thereof with pharma

Details Absorption-promoting compounds, compositions thereof with pharma Absorption-promoting compounds, compositions thereof with pharma

1981-03-24

1984-04-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

424177, 424180, 424181, 424183, 424203, 424246, 424251, 424274, 424270, 4242485, 42424854, 42424855, 424358, 424DIG15, A61K 3726, A61K 3700, A61K 3154, A61K 31425

Patent

active

044420900

ABSTRACT:
Compounds satisfying four specific requirements, namely: (1) a log P value in the range of from 2.5 to 6, (2) a molecular structure with at least one carboxyl group, (3) a pKa value for the carboxyl group of not less than 2.5 and (4) absence of halo substitution, and nontoxic salts thereof promote absorption of pharmacologically-active substance through the rectum into the bloodstream and are effective to raise the concentration of such active substance in the bloodstream even when the active substance is usually unabsorbable or absorbable through the rectum only with considerable difficulty. The compounds are combined with pharmacologically-active ingredients, with pharmaceutical bases suitable for rectal administration of drugs and with appropriate combinations of both.

REFERENCES:
patent: 4277465 (1981-07-01), Kamada
patent: 4338306 (1982-07-01), Kitao et al.

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