Absorption enhancers for drug administration

Details Absorption enhancers for drug administration Absorption enhancers for drug administration

1993-06-24

1997-08-26

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 24, 514 53, 514 54, 514912, 514 2, 514 3, 514 8, 536 41, 536115, 536116, 536118, 536120, 536122, 53612313, C07G 300, A61K 3170, A61K 3800, A61K 3828

Patent

active

056611307

ABSTRACT:
The present invention relates to a method of increasing the absorption of a compound via the ocular, nasal, nasolacrimal or inhalation route into the circulatory system of a patient. In particular, a method comprising administering with the compound an absorption enhancer comprising a nontoxic, nonionic alkyl glycoside is provided. Additionally provided are methods of raising or lowering the blood glucose level by administering glucagon or insulin, respectively, with such absorption enhancers. Finally, compositions for raising or lowering the blood glucose level are provided.

REFERENCES:
patent: 4868289 (1989-09-01), Magnusson et al.
patent: 5182258 (1993-01-01), Chiou
patent: 5369095 (1994-11-01), Kee et al.
Masahiro Murakami et al., "Assessment of Enhancing Ability of Medium-Chain Alkyl Saccharides as New Absorption Enhancers in Rat Rectum," International Journal of Pharmaceutics, 79:159-169 (1992).
Lars Hovgaard et al., "Insulin Stabilization and GI Absorption," Journal of Controlled Release, 19:99-108 (1992).
Dennis J. Pillion et al., "Systemic Absorption of Insulin Delivered Topically to the Rat Eye," Investigative Ophthalmology & Visual Science, 32(12):3021-3027 (Nov. 1991).
Taro Ogiso et al., "Percutaneous Absorption of Elcatonin and Hypocalcemic Effect in Rat," Chem. Pharm. Bull., 39(2):449-453 (1991).
Akira Yamamoto et al., "The Ocular Route for Systemic Insulin Delivery in the Albino Rabbit," The Journal of Pharmacology and Experimental Therapeutics, 249(1):249-255 (1989).
George C.Y. Chiou et al., "Systemic Delivery of Insulin Through Eyes to Lower the Glucose Concentration," Journal of Ocular Pharmacology, 5(1):81-91 (1989).
George C.Y. Chiou et al., "Improvement of Systemic Absorption of Insulin Through Eyes with Absorption Enhancers," Journal of Pharmaceutical Sciences, 78(10):815-818 (Oct. 1989).
G. S. Gordon et al., "Nasal Absorption of Insulin: Enhancement by Hydrophobic Bile Salts," Proc. Natl. Acad. Sci, USA, 82:7419-7423 (Nov. 1985).
Robert Salzman et al., "Intranasal Aerosolized Insulin," The New England Journal of Medicine, 312(17):1078-1084 (Apr. 25, 1985).
Alan C. Moses et al., "Insulin Administered Intranasally as an Insulin-Bite Salt Aerosol -Effectiveness and Reproducibility in Normal and Diabetic Subjects," Diabetes, 32:1040-1047 (Nov. 1983).

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