Absorption enhancers

Details Absorption enhancers Absorption enhancers

2007-12-04

2007-12-04

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C424S452000, C424S009100, C514S012200, C514S946000, C530S350000

Reexamination Certificate

active

10398228

ABSTRACT:
The invention relates to the use of hydrophilic aromatic alcohols to enhance the uptake of molecules, including biologically active macromolecules, into the body across the intestinal wall from the lumen of the gut; to compositions for oral administration which consists of an enteric capsule capable of withstanding transit through the stomach, containing a mixture comprising: (a) an active principal, and (b) a hydrophilic aromatic alcohol absorption enhancer; and to the user of the composition in medical treatment and diagnosis.

REFERENCES:
patent: 4804541 (1989-02-01), Nichols
patent: 5196184 (1993-03-01), Burghart et al.
patent: 6485706 (2002-11-01), McCoy et al.
patent: 0 371 010 (1990-05-01), None
patent: WO 93 06854 (1993-04-01), None
Asada et al.,J Pharm Sci84 682-7 (1995) “Absorption characteristics of chemically-modified insulin derivatives with various fatty acids in the small and large intestine.”
Bai et al.,Crit Rev Ther Drug Carrier Syst12 339-71 (1994) “Targeting of peptide and protein drugs to specific sites in the oral route.”
Fagerholm et al.,J Pharm Pharmacol50 467-73 (1998) “The effect of a drug delivery system consisting of soybean phosphatidyl choline and medium chain monoacyl glycerol on the intestinal permeability of hexarelin in the rat.”
Morishita et al.,Biol Pharm Bull16 68-72 (1993) “Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycholate on intestinal absorption of insulin.”
Saunders et al.,Gut16 543-8 (1975) “Regional differences in oxalate absorption by rat intestine: evidence for excessive absorption by the colon in steatorrhoea.”
Wang et al.,Biol Pharm Bull17 1399-403 (1994) “Mechanism of gastrointestinal absorption of glycyrrhizin in rats.”
Yamamoto et al.,J Pharm Pharmacol49 1057-61 (1997) “Effects of different absorption enhancers on the permeation of ebiratide, an ACTH analogue, across intestinal membranes.”

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