Absorbent of .beta..sub.2 -microglobulin

Details Absorbent of .beta..sub.2 -microglobulin Absorbent of .beta..sub.2 -microglobulin

1990-04-19

1991-09-24

Jones, W. Gary

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210679, 210692, 2105021, 210905, 502402, 502403, 502404, 525 541, 530354, 530356, 530394, 530413, 530415, 530813, 530815, B01D 1508

Patent

active

050511858

ABSTRACT:
An adsorbent for .beta..sub.2 -microglobulin is disclosed, which comprises a water-insoluble carrier having supported thereon, as a ligand, at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide, a synthetic high polymer, collagen having an isoelectric point of 9.5 or more, and gelatin having an isoelectric point of 6.5 or more, wherein said electrolyte has a molecular weight not less than 1,000 and an X value of more than 2.0, wherein X is a relationship regarding the skeleton structure of said electrolyte and is the sum of A and B, wherein A represents (the number of carbon atoms of the skeleton structure)-(the number of hydrophilic groups)/(the number of hydrophilic groups); and B represents .vertline.(the number of cationic groups)-(the number of anionic groups).vertline./(the number of hydrophilic groups). The adsorbent exhibits adsorptivity for .beta..sub.2 -microglobulin at high efficiency and high selectivity.

REFERENCES:
patent: 4171283 (1979-10-01), Nakashima et al.
patent: 4411532 (1983-10-01), Cuatrecasas et al.
patent: 4721730 (1988-01-01), Furuyoshi et al.
4535 A.S.A.I.O. Transactions, 33(1987) Sep., No. 3 Removal of Beta-2-Microglobulin by Direct Hemoperfusion with a Newly Developed Absorbent, Akizawa et al.
Chemical Abstract vol. 109, 1988.

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