Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1995-04-26
1997-10-21
Weiss, John G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424443, 424444, 604289, 604290, A61L 1500, A61F 1300, A61M 3500
Patent
active
056793723
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to an absorbable topical hemostat comprising a cotton-like product of collagen fibers to be used in the field of surgery, particularly to an absorbable topical hemostat which can be applied rapidly and effectively to hemorrhage from parenchymatous internal organs and capillary hemorrhage.
BACKGROUND ART
As a hemostatic method during a surgical operation, there may be mentioned a compression method, a ligation method, an electrocoagulation method, application of a physiologically active substance such as thrombin, fibrin paste, etc. and others. To an arterial hemorrhage with clear hemorrhagic sites, a ligation method or an electrocoagulation method has generally been applied. In the case of a venous hemorrhage, hemostasis is easily and sufficiently obtained by compression. However, these hemostatic methods are sometimes ineffectual to control a hemorrhage from parenchymatous internal organs and capillary hemorrhage, and when there is a tendency of hemorrhage in hepatic insufficiency or in the field of cardiovascular surgery, hemostasis is particularly difficult. In such a case, an absorbable topical hemostat which accelerates a blood coagulation reaction only by contacting it with a bleeding surface, whereby thrombus is formed rapidly to inhibit hemorrhage, is effective since not only is operation time shortened, but also postoperative rehemorrhage is prevented, to contribute to safe postoperative control. For this purpose, various topical hemostats using oxidized cellulose as a material have been developed and applied clinically. They have advantages that they are inexpensive and have excellent handling property, but they have disadvantages that since they do not use a material derived from an animal body, absorption into a living body is slow, and a strong hemolysis reaction and a reaction rejecting a foreign body are caused. In recent years, topical hemostats using collagen which is protein derived from an animal body have frequently been applied clinically since the collagen has low antigenicity and is absorbed into a living body safely to minimize an allergic reaction and a reaction rejecting a foreign body and further the collagen itself also has physiological functions (coagulation of platelets by adhesion, acceleration of a blood coagulation system by the platelet factor III released from coagulated platelets and formation of thrombus) thus, its hemostatic effect is high.
Topical hemostats made of collagen which have been put to practical use at present include those in which microfibrils of collagen are made flaky and those in which a collagen sponge is made plate-shaped. As to the former, telopeptide which is a determinant of antigenicity of collagen remains to exhibit antigenicity in a living body, so that they are required to be removed after use, they are flaky, so that they are flowed by blood to be scattered, whereby a large hemostatic effect cannot be expected, and they are easily charged with static electricity, so that there is a drawback in handling that they are easily attached to hands and tweezers during use. On the other hand, as to the latter, some of them comprise atelocollagen in which telopeptide has been removed, but they are plate-shaped, so that adhesiveness to a wound surface with a complicated shape is not sufficient and also astriction cannot be carried out, whereby a large hemostatic effect cannot be expected similarly as in the former.
As a material which can solve the above drawbacks, cotton-like topical hemostats comprising atelocollagen have been published. There may be mentioned, for example, a material obtained by spinning atelocollagen derived from porcine skin, drying it and forming it into a cotton-like product (Shimizu et al., Artificial Internal Organs 19 (3), 1235 (1990)), a material obtained by treating spun collagen with a crosslinking agent, washing it and lyophilizing it to be formed into a cotton-like product with a surface on which fine crack-like fissures are made (Japanese Provisional Patent Publication No. 6186
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patent: 5512291 (1996-04-01), Li
"A New Collagen Topical Hemostatic Agent-Comparative Evaluation In Experimental Animal Wounds", Jpn Artif Organs 19(3),1235-1238 (1990).
Akasaka Masanori
Makihara Toshikazu
Natsume Toru
Sakakibara Hiroki
Shimuzu Yasuhiko
Cho David J.
Mitsubishi Chemical Corporation
Nippon Meat Packers, Inc.
Shimizu Yasuhiko
Weiss John G.
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