ABL-interactor protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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530328, 530300, 435 691, 536 235, C07K 1445, C07H 2104, C12P 2100

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active

059691018

ABSTRACT:
The present invention relates to a protein that interacts with the cAbl protein tyrosine kinase and to a nucleic acid sequence encoding same. The invention also relates to complexes of the protein of the invention and cAbl and to the use of such complexes in the identification of therapeutic and diagnostic agents.

REFERENCES:
Cicchetti P; Mayer B J; Thiel G; Baltimore D. Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science, (Aug. 7, 1992) 257 (5071) 803-6.
Cicchetti et al, "3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts", The EMBO Journal 14(13):3127-3135 (1995).
Dai et al, "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity", Genes & Development 9:2569-2582 (1995).
Shi et al, "Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity", Genes & Development 9:2583-2597 (1995).
Dai et al, "Cloning and Characterization of a cABL Interacting Protein", Abstract/Tenth Annual Meeting on Oncogenes, p. 338, Jun. 21-25, 1994, Hood College, Frederick, Maryland.
Feller et al, "SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl", TIBS 19, Nov. 1994.
Taniuchi et al, "Antigen-receptor induced clonal expansion and deletion of lymphocytes are imparied in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases", The EMBO Journal 14(15):3664-3678 (1995).
Fukuda et al, "Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate", Proc. Natl. Acad. Sci. USA 92:7302-7306 (1995).
Zappavigna et al, "Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain", Genes & Development 8:732-744 (1994).
Kharbanda et al, "Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents", Nature 376:785-788 (1995).
Reddy et al. The cloning and characterization of a localized maternal transcript in Xenopus laevis whose zygotic counterpart is detected in the CNS. Mechanisms of Development, (Dec. 1992) 39 (3) 143-50.
Schulz et al. Principles of Protein Structure. (1979) Publisher: (Springer-Verlag, New York, N. Y.), 314 pages, see pp. 14-16.
Ren R. PIR-International Protein Sequence Database Accesion No. G01936, National Biomedical Research Foundation, Washington, DC 20007, Dec. 21, 1990.
Lowenstein et al, "The SH2 and SH3 Domain-Containing Protein GRB2 Links Receptor Tyrosine Kinases to ras Signalling", Cell 70:431-442 (1992).

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