Abiotic heparin antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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Details

C554S107000, C514S548000, C514S551000

Reexamination Certificate

active

07465820

ABSTRACT:
The present invention relates to heparin-binding calixarene compounds of general Formula (I) in which R, R1, L and n have the meanings indicated in the description and their use in the biomedical field.

REFERENCES:
patent: 5409959 (1995-04-01), Hwang et al.
Manabe (Chem. Abstract 1988:570,072, abstract of JP 62265250).
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaft, Frankfurt Am Main, DE; XP002317711 retrieved rom XFIRE Database accession No. 8824309, 8823238, 7679682 abstract & Eur. J. Org. Chem., vol. 3, 2001, pp. 595-602.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaft, Frankfurt Am Main, DE; XP002317712 retrieved from XFIRE Database accession No. 8246996, 8248224, 8247802, 8247910, 5201176 abstract & J. Prakt. Chem.-Ztg.,viol. 341, No. 3, 1999, pp. 264-273.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaft, Frankfurt Am Main, DE; XP002317713 retrieved from XFIRE Database accession No. 522504 abstract & J. Am. Chem Soc., vol. 111, No. 14, 1989, pp. 5477-5478.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaft, Frankfurt Am Main, DE; XP002317714 retrieved from XFIRE Database accession No. 7789075 abstract & J. Am. Chem. Soc., vol. 119, No. 24, 1997, pp. 5706-5712.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaft, Frankfurt Am Main, DE; XP002317715 retrieved from XFIRE Database accession No. 7563513 abstract & Angew. Chem., vol. 108, No. 12, 1996, pp. 1425-1427.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaft, Frankfurt Am Main, DE; XP002317716 retrieved from XFIRE Database accession No. 91109666 abstract & Org. Lett., vol. 4, No. 10, 2002, pp. 1687-1690.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wissenschaft, Frankfurt Am Main, DE; XP002317717 retrieved from XFIRE Database accession No. 9539937 abstra=ct & New J. Chem. vol. 26, No. 5, 2002, pp. 651-655.
Reeza Zadmard et al: “Capsule-like Assemblies in Polar Solvents” J. Org. Chem., vol. 68, No. 17, Jul. 24, 2003, pp. 6511-6521, XP002317709 p. 6515, fig. 7, compounds 17, 18.
Database Beilstein Beilstein Institut Zur Forderung Der Chemischen Wisenschaft, Frankfurt Am Main, DE; XP002317718 retrieved from XFIRE Database accession No. 5466493 abstract & J. Org. Chem., vol. 57, No. 13, 1992, pp. 3658-3662.
Database CAPLUS ′Online! Chemical Abstracts Service, Chemical Abstracts Service, Columbus, Ohio, US; Iwata, Kazunori et al Iwata, Kazunori et al: “Supports for adsorption chromatography Supports for adsorption chromatography” XP002317719 retrieved from STN Database accession No. 1994:338122 abstract & JP 05 264531 A2 (Showa Denko KK, Japna Showa Denko KK, Japan) Oct. 12, 1993.
Database CAPLUS ′Online! Chemical Abstracts Service, Columbus, Ohio US; Jakobi, Ralf A. et al: “Long-chain alkyl ethers of p-nitro- and p-aminocalixarenes” XP002317720 retrieved from STN Database accession No. 1996:287626 abstract & New Journal of Chemistry , 20(4), 493-501 coden: NJCHE5; ISSN: 1144-0546, 1996.
Tommasao Mecca et al: ‘Design calix’8!arene-based ligands for selective tryptase surface recognition Bioorg. Med. Chem.M vol. 12, Aug. 20, 2004, pp. 5057-5062, xp002317710 p. 5061: compounds 2-6 and their trifluoroacetic salts.
Consoli G M L et al: “Calix'8!arene-based glycoconjugates as multivalent carbohydrate-presenting systems” Tetrahedron Letters, Elsevier Science Publishers, Amssterdam, NL, vol. 44, No. 40, Sep. 29, 2003, pp. 7467-7470, XP004453448 ISSN: 0040-4039 p. 7468, compound 1.

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