Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-12-22
2010-02-23
Hui, San-ming (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S691000, C514S712000, C514S766000, C514S824000
Reexamination Certificate
active
07666900
ABSTRACT:
To provide a pharmaceutically effective prophylactic/preventive agent for low-HDL cholesterolemia, focusing on an HDL-generating mechanism. The ABCA1 stabilizer of the present invention contains a bisphenol-type compound selected form probucol spiroquinone, probucol diphenoquinone, and probucol bisphenol as an effective ingredient. The ABCA1 stabilizer can continuously and stably express ABCA1 by a mechanism quite different from that of conventional processes, and thus is useful as prophylactic/preventive agent for low-HDL cholesterolemia or arteriosclerosis.
REFERENCES:
patent: 97/38681 (1997-10-01), None
patent: 01/77072 (2001-10-01), None
patent: 02/04031 (2002-01-01), None
Matsuzawa Y, Yamashita S, Funahashi T, Yamamoto A, and Tarui S, “Selective reduction of cholesterol in HDL2 fraction by probucol in familial hypercholesterolemia and hyperHDL2 cholesterolemia with abnormal cholesteryl ester transfer,” American Journal of Cardiology, Jul. 1988, 62(3), 66B-72B (abstract only).
Tardif JC, Grégoire J, Lavoie MA, and L'Allier PL, “Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies,” Current Opinion in Lipidology, 14(6), 615-620.
McLean, Larry et al., “Interactions of MDL 29,311 and Probucol Metabolites with Cholesteryl Esters”Lipids, vol. 29, No. 12, pp. 819 to 823 (1994).
Oram, J. F., “HDL Apolipoproteins and ABCA1: Partners in the Removal of Excess Cellular Cholesterol”Arterioscler. Thromb. Vasc. Biol., vol. 23, No. 5, pp. 720 to 727 (2003).
Aotsuka Tomoji
Arakawa Reijiro
Tsujita Maki
Yokoyama Shinji
Hui San-ming
Hykes Laboratories LLC
Wenderoth Lind & Ponack, LLP.
Zarek Paul
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