AAV vector for gene therapy

Details AAV vector for gene therapy AAV vector for gene therapy

2004-06-09

2009-12-08

Epps-Smith, Janet L (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S093200, C435S456000

Reexamination Certificate

active

07629322

ABSTRACT:
Described are recombinant AAV vectors characterized in that they carry capsid protein modification(s) resulting in a reduced or eliminated heparin binding function. The AAV vectors of the present invention are particularly suitable for gene therapy by systemic application, since (a) transduction of the liver is eliminated or at least drastically reduced and (b) the transduction efficiency of non-hepatic tissues is increased.

REFERENCES:
patent: 6162796 (2000-12-01), Kaplitt et al.
patent: 6962815 (2005-11-01), Bartlett
patent: 2006/0088936 (2006-04-01), Warrington et al.
patent: WO 2004/027019 (2004-04-01), None
Grifman M, Trepel M, Speece P, Gilbert LB, Arap W, Pasqualini R, and Weitzman MD. Incorporation of Tumor-Targeting Petides into Recombinant Adeno-associated Virus Capsids. Molecular Therapy 3(6): 964-975. Jun. 2001.
Verma et al (Nat. 1997 Sep; 389:239-242).
Eck et al. (Phar Basis Ther 1995; 77-101).
Xie et al. PNAS 2002; 99(16):10405-10410.
Wu Xiao (PhD Dissertation 2002, University of Florida).
Kern A. et al: “Identification of a Heparin-Binding Motif on Adeno-Associated Virus Type 2 Capsids”, Journal of Virology, Oct. 2003, pp. 11072-11081.
Opie S. R. et al: “Identification of Amino Acid Residues in the Capsid Proteins of Adeno-Associated Virus Type 2 That Contribute to Heparan Sulfate Proteoglycan Binding”, Journal of Virology, Jun. 2003, pp. 6995-7006.

Affiliated with

Also associated with

Rating

AAV vector for gene therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with AAV vector for gene therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and AAV vector for gene therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4090266