AAV DNA comprising helper virus sequences

Details AAV DNA comprising helper virus sequences AAV DNA comprising helper virus sequences

2006-12-12

2006-12-12

Winkler, Ulrike (Department: 1648)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C424S199100, C424S233100, C435S069100, C435S320100, C435S456000, C435S457000, C536S023100, C536S023400

Reexamination Certificate

active

07148341

ABSTRACT:
The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both.

REFERENCES:
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patent: 6004797 (1999-12-01), Colosi
patent: WO 95/06743 (1995-03-01), None
patent: WO 96/18727 (1996-06-01), None
Bett et al. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proceedings of the National Academy of Science (1994) vol. 91, pp. 8802-8806.
Chartier et al., 1996, “Efficient Generation of Recombinant Adenovirus Vectors by Homologous Recombination inEscherichia coli,” Journal of Virology 70(7):4805-4810.
Clark et al., 1995, “Cell Lines for the Production of Recombinant Adeno-Associated Virus,”Human Gene Therapy 6(10):1329-1341.
Colosi et al., 1995, “AAV Vectors Can Be Efficiently Produced Without Helper Virus,”Blood 86(10 Suppl. 1):627A.
Fasel et al., 1982, “The region of mouse mammary tumor virus DNA containing the long terminal repeat includes a long coding sequence and signals for hormonally regulated transcription,”EMBO Journal 1(1):3-7.
Flotte et al., 1995, “An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction,”Gene Therapy 2(1):29-37.
Laughlin et al., 1983 “Cloning of infectious adeno-associated virus genomes in bacterial plasmids,”Gene 23(1):65-73.
Stratford-Perricaudet et al., 1992, “Widespread Long-term Gene Transfer to Mouse Skeletal Muscles and Heart,”J. Clin. Invest 90:626-630.

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