Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-06-06
1998-06-30
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Vector, per se
4351723, 435325, 435 691, 514 44, 800 2, 935 23, 935 24, 935 32, 935 6, 935 55, 935 57, 935 70, C12N 1563, C12N 500, C12N 1500
Patent
active
057732892
ABSTRACT:
The present invention relates to novel recombinant AAV (Adeno-associated virus) vectors that may be used to direct integration of recombinant DNA sequences into specific regions of the human host genome. These vectors may be used in gene therapies designed to replace or supplement defective genetic information with normal genetic information. The invention also relates to the isolation and characterization of the specific cellular host sequences, herein referred to as host target sequences, that signal the integration of AAV recombinant DNA sequences into specific regions of the host genome. Transgenic animals containing the generated target sequences may be as used as model is systems for testing of AAV based gene therapies.
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Samulski Richard Jude
Xiao Xiao
Chambers Jasemine C.
Schmuck Jill D.
University of Pittsburgh
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