Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1995-06-06
1999-01-26
Guzo, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
4242041, 4242341, 4351721, 4351723, 4352351, 4353201, A61K 3902, A61K 3912, C12N 701, C12N 704
Patent
active
058635416
ABSTRACT:
The invention relates to the production of AAV capsids which may be used to transfer native or heterologous molecules into appropriate host cells. The capsid proteins can be expressed from a recombinant virus, expression vector, or from a cell line that has stably integrated the AAV capsid genes or coding sequences. The invention further provides for the production of AAV capsids in vitro from the AAV capsid proteins and the construction of packaged capsids in vitro. The invention further provides for the production of AAV capsids that have been genetically engineered to express heterologous epitopes of clinically important antigens to elicit an immune response.
REFERENCES:
patent: 4797368 (1989-01-01), Carter et al.
patent: 5354678 (1994-10-01), Lebkowski et al.
Flotte et al., 1993, "Expression of the Cystic Fibrosis Transmembrane Conductance Regulator from a Novel Adeno-Associated Virus Promoter", J. Biol. Chem. 268:3781-3790.
Ruffing et al., 1992, "Assembly of Viruslike Particles by Recombinant Structural Proteins of Adeno-Associated Virus Type-2 in Insect Cells", J. Virol. 66:6922-6930.
Tratschin et al., 1985, "Adeno-Associated Virus Vector for High-Frequency Integration, Expression, and Rescue of Genes in Mammalian Cells", Mol. Cell. Biol. 5:3251-3260.
Klavinskis et al., J. Virol., vol. 63, No. 10, pp. 4311-4316, 1989.
Ellis et al., J. Med. Virol., vol. 3, pp. 54-58, 1990.
Hurby, Clin. Micro. Rev., vol. 3 No. 2, pp. 153-170, 1990.
Rouse et al., Rev. Infect. Dis., vol. 10, No. 1 pp. 16-33, 1988.
Jaenicke, Prog. Biophys. Molec. Biol., vol. 49, pp. 117-237, 1987.
Kirnbauer et al., 1993, "Efficient Self-Assembly of Human Papillomavirus Type 16L1 and L1-L2 into Virus-Like Particles," J. Virol. 67(12):6929-6936.
Hagensee et al., 1993, "Self-Assembly of Human Papillomavirus Type 1 Capsids by Expression of the L1 Protein Alone or by Coexpression on the L1 and L2 Capsid Proteins," J. Virol. 67(1):315-322.
Gonzalesz, et al., 1993, "Assembly of the Matrix Protein of Simian Immunodeficiency Virus into Virus-like Particles," Virology 194:548-556.
Morgan et al., 1993, "Human Gene Therapy," Annu. Rev. Biochem. 62:191-217.
Ruffing et al., 1992, "Assembly of Virus like Particles by Recombinant Structural Proteins of Adeno-Associated Virus Type 2 in Insect Cells," J. Virol. 66:6922-6930.
Gossen et al., 1992, "Tight Control of Gene Expression In Mammalian Cells by Tetracycline-Responsive Promoters,"Proc. Natl. Acad. Sci. 89:5547-5551.
Clemens et al., 1992, "Expression of Aleutian Mink Disease Parvovirus Capsid Proteins Recombinant Vaccinia Virus: Self-Assembly of Capsid Proteins into Particles," J. Virol. 66:3077-3085.
Berkner, K. L., 1992, "Expression of Heterologous Sequences in Adenoviral Vectors," Curr. Topics in Microbiology and Immunol. 158:39-66.
Muzyczka, N. 1992, "Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells," Curr. Topics in Microbiology and Immunol. 158:97-129.
Kajigaya et al., 1991, "Self-Assembled B19 Parvovirus Capsids, Produced in a Baculovirus System, are Antigenically and Immunologically Similar to Native Virons," Proc. Natl. Acad. Sci. USA 89:4646-4650.
Samulski et al., 1991, "Targeted Integration of Adeno-Associated Virus (AAV) into Human Chromosome 19," EMBO 10:3941-3950.
Kotin et al., 1990 "Site-Specific Integration by Adeno-Associated Virus," Proc. Natl. Acad. Sci. USA 87:2211-2215.
Samulski et al., 1989, "Helper-Free Stocks of Recombinant Adeno-Associated Virses: Normal Integration Does Not Require Viral Gene Expression," J. Virol. 63:3822-3828.
Dolph et al., 1988, "The Adenovirus Tripartite Leader May Eliminate the Requirement for Cap-Binding Protein Complex during Translation Initiation," J. Virol. 62(6):2059-2066.
Samulski et al., 1987, "A Recombinant Plasmid from Which an Infectious Adeno-Associated Virus Genome Can Be Excised In Vitro and Its Use To Study Viral Replication," J. Virol. 61(10):3096-3101.
Sanes et al., 1986, "Use of a Recombinant Retrovirus to Study Post-Implantation Cell Lineage in Mouse Embryos," EMBO 5:3133-3142.
Srivastava et al., 1983, "Nucleotide Sequence and Organization of the Adeno-Associated Virus 2 Genome," J. Virol.
Myers et al., 1980, "Assembly of Adeno-Associated Virus" Virology 102:71-82.
Hoggan et al., 1966, "Studies of Small DNA Viruses Found in Various Adenovirus Preparations: Physical, Biological, and Immunological Characteristics," Proc. Natl. Acad Sci. 55:1467-1474.
Orkin et al., "Report and Recommendations of th Panel to Assess the NIH Investment in Research on Gene Therapy", Dec. 1995.
Ferrari Forrest K.
Samulski Richard Jude
Guzo David
University of Pittsburgh
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