A89271 factors and processes for their production

Details A89271 factors and processes for their production A89271 factors and processes for their production

1994-07-08

1995-10-10

Brust, Joseph P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548417, 548419, 548425, A61K 31275, C07D20994, C07D40502

Patent

active

054571197

ABSTRACT:
New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.

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