A87689 compounds

Details A87689 compounds A87689 compounds

1994-04-28

1995-09-19

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435195, 4352521, 4352532, 4352535, C12P 104, A61K 3500

Patent

active

054514037

ABSTRACT:
Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.

REFERENCES:
patent: 5278064 (1992-05-01), Berry et al.
A. Fredenhagen, G. Fendrich, F. Marki, J. Gruner, F. Raschdorf, and H. Pete"Duramycins B and C. Two New Lanthionine Containing Antibiotics as Inhibito of Phospholipase A2," J. Antibiotics 43: 1403-1412 (1990).
K. Nakagawa and A. Torikata, "Microbial Conversion of Milbemycins: 30-Oxidation of Milbemycin A.sub.4 and related Compounds by Amycolatopsis autotrophica and Amycolatopsis mediterranei," J. Antibiotics 43: 1321-1328 (1990).
Kusumi, T., et al., The Structures of Quartromicins A1, A2, A3: Novel Macrocyclic Antiviral Antibiotics Possessing Four Tetronic Acid Moieties, J. Am. Chem. Soc., 113: 8947-8948 (1991).

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