Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1990-02-20
1992-03-10
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 530806, 424 92, 435232, C07K 1504, C07K 1514
Patent
active
050950940
ABSTRACT:
The proteins of the invention are specifically recognized by polyclonal anti-AC antibodies raised against purified AC preparations, devoid of adenylate cyclase CaM-activable activity and devoid of affinity for CaM.
REFERENCES:
patent: 4279884 (1981-07-01), Bradwell et al.
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Development in Biological Standardization, 1985, pp. 27-42, P. Novotny et al.: "Bordetella Adenylate Cyclase: A Genus Specific Protective Antigen and Virulence Factor".
Journal of Infections Diseases, vol. 3, 1977, pp. S216-S219; E. L. Hewlett et al.: "Adenyl Cyclase in Bordetella Pertussis Vaccines".
Infection and Immunity, vol. 50, No. 1, Oct. 1985, pp. 199-206, American Society for Microbiology; P. Novotny et al.: "Adenylate Cyclase Activity of a 68.000-Molecular-Weight Protein Isolated from the Outer Membrane of Bordetella bronchiseptica".
Chemical Abstracts, vol. 105, No. 21, 24th Nov. 1986, p. 311, Abstract No. 186455s, Columbus, Ohio, US; D. Ladant et al.: "Bordetella Pertussis Adenylate Cyclase. Purification Characterization, and Radioimmunoassay" & J. Biol. Chem. 1986, 261(34), 16264-16269.
Ladant, D. 1988 J. Biol. Chem. 263(6):2612-2618.
Glaser et al. 1989, The EMBO Journal 8(3):967-972.
Alonso Jean M.
Boucaud Jean Luc
Brezin Colette
Nghiem Hoang-Oanh
Furman Keith C.
Institut National de la Sante et de la Recherche Medicale
Institut Pasteur
Moskowitz Margaret
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