A41030 antibiotics

Details A41030 antibiotics A41030 antibiotics

1984-10-18

1985-08-27

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

2601125R, 260112R, A61K 3500, C07C10352, C07G 700

Patent

active

045377707

ABSTRACT:
Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antiobiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.

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patent: 3952095 (1976-04-01), Hamill et al.
patent: 4115552 (1978-09-01), Hamill et al.
patent: 4239751 (1980-12-01), Coronelli et al.
patent: 4322343 (1982-03-01), Debono
patent: 4322406 (1982-03-01), Debono et al.
Williamson et al., "Structure Revision of the Antibiotic Vancomycin. The Use of Nuclear Overhauser Effect Difference Spectroscopy", J. Am. Chem. Soc. 103, 6580-6585, 1981.
Kalman et al., "An NMR Study of the Antibiotic Ristocetin A. The Negative Nuclear Overhauser Effect in Structure Elucidation", J. Am. Chem. Soc. 102, 897-905 (1980).
Ellestad et al., "Avoparcin and Epiavoparcin", J. Am. Chem. Soc. 103, 6522-6524 (1981).
Derwent Abstract 83-840048/50 of West German OLS 3320-342-A (Gruppo Lepetit SPA).
Hunt et al., "Structure of the Major Glycopeptide of the Teicoplanin Complex", J. Amer. Chem. Soc. 106, 4891-4895 (1984).
Barna et al., "Structure Elucidation of the Teichoplanin Antibiotics", ibid 106, 4895-4902 (1984).

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