Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-05-30
1998-03-31
Caputa, Anthony C.
Chemistry: molecular biology and microbiology
Vector, per se
435 693, 536 235, C12N 1563, C12N 1512
Patent
active
057337780
ABSTRACT:
Differentially expressed Leishmania genes and proteins are described. One differentially expressed gene (A2) is expressed at significantly elevated levels (more than about 10 fold higher) in the amastigote stage of the life cycle when the Leishmania organism is present in macrophages than in the free promastigote stage. The A2 gene encodes a 22 kD protein (A2 protein) that is recognized by kala-azar convalescent serum and has amino acid sequence homology with an S-antigen of Plasmodium falciparum Vietnamese isolate VI. Differentially expressed Leishmania genes and proteins have utility as vaccines, diagnostic reagents, as tools for the generation of immunological reagents and the generation of attenuated variants of Leishmania.
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Chareat Hugues
Matlashewski Gregory
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