A1 adenosine receptro antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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Details

C544S244000, C544S251000, C514S267000

Reexamination Certificate

active

07022686

ABSTRACT:
Compounds of Formula I and II are disclosed as antagonists of subtype A1 adenosine receptors. These compounds are useful for treatment of various diseases and disorders, including systemic hypertension, renal failure, diabetes, asthma, an edematous condition, congestive heart failure, and renal dysfunction.

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PDR Medical Dictionary p. 544 (First ed. 1995).
International Encyclopedia of Chemical Science (1964) p. 899.
M. J. Dooley et al. “Theoretical Structure-Activity Studies of Adenosine A1 Ligands: Requirements for Receptor Affinity”,Bioorg. Med. Chem., 4(6), 1996, pp. 923-934.

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