Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Patent
1998-04-15
2000-09-12
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
544272, A61K 3152, C07D47306
Patent
active
061179981
ABSTRACT:
A compound useful as an A.sub.1 adenosine receptor antagonist has the formula: ##STR1## wherein R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.8 alkyl;
REFERENCES:
patent: 2887486 (1959-05-01), Leake et al.
patent: 3031451 (1962-04-01), Schlesinger et al.
patent: 3309271 (1967-03-01), Georges et al.
patent: 3317533 (1967-05-01), De Ridder
patent: 3961060 (1976-06-01), Fuxe
patent: 4092417 (1978-05-01), Credner et al.
patent: 4299832 (1981-11-01), Brown et al.
patent: 4378359 (1983-03-01), Chiodoni et al.
patent: 4548818 (1985-10-01), Kjellin et al.
patent: 4612315 (1986-09-01), Jacobson et al.
patent: 4622324 (1986-11-01), Klessing et al.
patent: 4696932 (1987-09-01), Jacobson et al.
patent: 4769377 (1988-09-01), Snyder et al.
patent: 4772607 (1988-09-01), Badger et al.
patent: 4868186 (1989-09-01), Franzone et al.
patent: 4968672 (1990-11-01), Jacobson et al.
patent: 4971972 (1990-11-01), Doll et al.
patent: 5032593 (1991-07-01), Rzeszotarski et al.
patent: 5066655 (1991-11-01), Olsson
patent: 5068236 (1991-11-01), Suzuki et al.
patent: 5208240 (1993-05-01), Peet et al.
patent: 5248770 (1993-09-01), Jacobsen
patent: 5256650 (1993-10-01), Peet et al.
patent: 5296463 (1994-03-01), Lee et al.
patent: 5298508 (1994-03-01), Jacobson et al.
patent: 5314890 (1994-05-01), Agostini et al.
patent: 5340813 (1994-08-01), Klein et al.
patent: 5395836 (1995-03-01), Shimada et al.
patent: 5434150 (1995-07-01), Austel et al.
patent: 5447933 (1995-09-01), Suzuki et al.
patent: 5532368 (1996-07-01), Kufner-Muhl et al.
patent: 5543415 (1996-08-01), Suzuki et al.
patent: 5545627 (1996-08-01), Jacobson et al.
Neely et al., AHA-Circulation, A.sub.1 Adenosine Receptor Antagonists block Ischemia-Reperfusion Injury of the Heart, vol. 94, No. 9 (Nov. 1, 1996), pp. 1-5.
Jacobson et al., Molecular Pharmacology, A Functionalized Congener Approach to Adenosine Receptor Antagonists: Amino Acid Conjugates of 1,3-Dipropylxanthine, vol. 29, pp. 126-133 (1985).
Van Galen et al., J. Med. Chem., A Model for the Antagonist Binding Site on the Adenosine A.sub.1 Receptor, Based on Steric, Electrostatic, and Hydrophobic Properties, vol. 33, pp. 1709-1713 (1990).
Jacobson et al., J. Med. Chem., Adenosine Receptors: Pharmacology, Strucutre-Activity Relationships, and Therapeutic Potential, vol. 35, No. 3, pp. 407-422 (Feb. 7, 1992).
Windholz, The Merck Index, Bamifylline, Tenth Edition, p. 952 (1983).
Suzaki J. Med. Chem., vol. 35, pp. 3578-3581 (1992).
Abbracchio et al., Pharmacological Research Communications, Selective Activity of Bamifylline on Adenosine A.sub.1 --Receptors in Rat Brain, vol. 19, No. 8, pp. 537-545 (1987).
Bio World Today, Others News to Note, p. 2 (Mar. 20, 1996).
Belliardo et al., Journal of Chromatography, Micro-Scale Liquid Chromatographic Method for the Determination of Bamifylline and its major Metabolite in human Plasma, pp. 305-309 (1990).
Schiantarelli et al., Arzneim.-Forsch., Evidence of Pulmonary Tropism of Bamifylline and its Main Active Metabolite, pp. 215-219 (1989).
Van Rhee et al., J. Med. Chem., Tetrahydrobenzothiophenone Derivitives as a Novel Class of Adenosine Receptor Antagonists, vol. 39, pp. 398-406 (1996).
Muller et al., J. Med. Chem., 7-Deaza-2-henyladenines: Structures-Activity Relationships of Potent A.sub.1 Selective Adenosine Receptor Antagonists, vol. 33, pp. 2822-2828 (1990).
Patel et al., Molecular Pharmacology, I-BW-A844U, an Antagonist Radioligand with High Affinity and Selectivity for Adenosine A.sub.1 Receptors, and .sup.125 I-Azido-BW-A844U, a Photoaffinity Label, vol. 33, pp. 585-591 (1988).
Carlucci et al., Journal of Pharmaceutical & Biomedical Analysis, Determination of Bamifylline Hydrochloride Impurities in Bulk Material and Pharmaceuticl Forms Using Liquid Chromatography with Ultraviolet Detection, vol. 8, pp. 1067-1069 (1990).
Berch Mark L.
Link Technology Incorporated
LandOfFree
A1 adenosine receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with A1 adenosine receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A1 adenosine receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-97479