A1 adenosine receptor agonists and antagonists as diuretics

Details A1 adenosine receptor agonists and antagonists as diuretics A1 adenosine receptor agonists and antagonists as diuretics

1993-10-28

1995-08-29

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544268, 544271, 544272, 536 2762, A61K 3152, C07D47306, C07D47308, C07D51900

Patent

active

054460468

ABSTRACT:
Adenosine and xanthine derivatives, and compositions comprising those compounds, are potent selective agonists and antagonists of adenosine receptors. The derivatives and composition are used to treat conditions, including certain cardiac arrhythmias.

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patent: 4980379 (1990-12-01), Belardinelli et al.
patent: 5288721 (1994-02-01), Klein
Jacobsen, J Med Chem 35, 407 (1992).
Belardinelli, L. et al. (1989) "The Cardiac Effects of Adenosine" Progress in Cardiovascular Diseases 32:73-97.
Belardinelli, L. et al. (1990) "Cardiac Electrophysiology and Pharmacology of Adenosine" J. Cardiovasc. Electrophysiol. 1:327-339.
Olsson, R. A., J. D. Pearson (1990) "Cardiovascular Purinoceptors" Physiological Reviews 70:761-845.

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