A.sup.21, B.sup.30, modified insulin derivatives having an alter

Details A.sup.21, B.sup.30, modified insulin derivatives having an alter A.sup.21, B.sup.30, modified insulin derivatives having an alter

1997-04-16

2000-08-08

Woodward, Michael P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530304, 514 3, 514 12, A61K 3828

Patent

active

06100376&

ABSTRACT:
New insulin derivatives of the formula II with an iso-electric point between 5 and 8.5, with improved stability in weakly acid aqueous medium and with a special action profile, and the physiologically tolerated salts of these insulin derivatives, for the treatment of diabetes mellitus; formula II is: ##STR1## in which R.sup.1 denotes H or H-Phe,

REFERENCES:
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patent: 4701440 (1987-10-01), Grau
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Burgermeister, W., et al., The Isolation of Insulin from the Pancreas, Reprint from the Handbook of Experimental Pharmacology, pp. 715-727 (1975).
Neubauer, "The Immunogenicity of Different Insulins in Several Animal Species," Diabetes, vol. 27, No. 1 (1977), pp. 8-15.
Markussen et al., "Soluble, prolonged-acting insulin derivatives. II. Degreee of protraction and crystallizability of insulins substituted in positions A17, B8, B13, B27 and B30," Protein Engineering 1(3):215-223 (1987).
J. Brange; Springer-Verlag, "Galenics Of Insulin, The Physico-chemical and Pharmaceuticl Aspects of Insulin and Insulin Preparations," Berlin Heidelberg, pp. 35-36.
Markussen et al., "Soluble prolonged-acting insulin derivatives. III. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions A21, B13, B23, B27, and B30," Protein Engineering 2(2):157-166 (1988).
Zinman, Bernard, "The Physiologic Replacement of Insulin," Medical Intelligence, vol. 32, No. 6, pp. 363-370 (1989).
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