A.sup.21 -, B.sup.30 - modified insulin derivatives having an al

Details A.sup.21 -, B.sup.30 - modified insulin derivatives having an al A.sup.21 -, B.sup.30 - modified insulin derivatives having an al

1994-09-12

1997-08-12

Lukton, David

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530304, A61K 3828

Patent

active

056567227

ABSTRACT:
New insulin derivatives, the use thereof, and a pharmaceutical composition containing them
Insulin derivatives having an isoelectric point between 5 and 8.5, or physiologically tolerated salts thereof, of the Formula II ##STR1## in which: R.sup.1 at position B1 denotes H or H-Phe;

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Neubauer, "The Immunogenicity of Different Insulins in Several Animal Species", Diabetes, vol. 27, No. 1 (1977).
"Galenics Of Insulin, The Physico-chemical and Pharmaceutical Aspects of Insulin and Insulin Preparations", J. BRANGE: Springer-Verlag Berlin Heidelberg 1987, pp. 35-36.
Markussen et al., Soluble, prolonged-acting insulin derivatives, II. Degree of protraction and crystallizability of insulins substituted in positions A17, B8, B13, B27 and B30, Protein Engineering 1(3):215-223 (1987).
Markussen et al., Soluble, prolonged-acting insulin derivatives, III. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions A21, B13, B23, B27, and B30, Protein Engineering 2(2):157-166 (1988).
Zinman, Bernard, The Physiologic Replacement of Insulin, Medical Intelligence, vol. 32, No. 6, pp. 363-370 (1989).
Sundby, F., Separation and Characterization of Acid-induced Insulin Transformation Products by Paper Electrophoresis in 7 M Urea, The Journal of Biological Chemistry, vol. 237, No. 11, pp. 3406-3411 (1962).
Burgermeister, W., et al., The Isolation of Insulin from the Pancreas, Reprint from the Handbook of Experimental Pharmacology, pp. 715-727 (1975) Insulin Humanum, European Pharmacopeia 838 (1993).

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