Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-08-22
1996-05-14
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 536 235, C07K 14705, F12N 1512
Patent
active
055168949
ABSTRACT:
Disclosed are cDNAs encoding A.sub.2b -adenosine receptors and the recombinant proteins expressed from such cDNAs. The recombinant receptor and receptor fragments and analogs are used in methods of screening candidate compounds for their ability to antagonize interaction between adenosine and an A.sub.2b -adenosine receptor; antagonists are used as therapeutics to reduce inflammatory gastrointestinal tract diseases or asthma. Antibodies specific for A.sub.2b -adenosine receptor (or receptor fragment or analog) and their use as a therapeutic and diagnostic are also disclosed.
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The General Hospital Corporation
Ulm John
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