A-seco steroids effective at treating ophthalmic pathological ne

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514174, 514175, 514557, A61K 31215, A61K 3158, A61K 31585, A61K 3119

Patent

active

059291117

ABSTRACT:
A-seco steroids are disclosed. Methods of use are disclosed for treating ophthalmic pathological neovascularization and controlling intraocular pressure.

REFERENCES:
patent: 2951074 (1960-08-01), Chemerda et al.
patent: 4052422 (1977-10-01), Cimarusti
patent: 4550022 (1985-10-01), Garabedian et al.
patent: 4771042 (1988-09-01), Braughler et al.
patent: 4863912 (1989-09-01), Southren et al.
patent: 4945089 (1990-07-01), Clark
A. Abad, Silica Gel Catalyzed Eschenmoser Reactioin, Synlett, pp. 787-788 (1991).
Ashino-Fuse, et al., Medroxyprogesterone Acetate, An Anti-Cancer And Anti-Angiogenic Steroid, Inhibits The Plasminogen Activator In Bovine Endothelial Cells, Int. J. Cancer, vol. 44, pp. 859-864 (1989).
BenEzra, Neovasculogenic Ability of Prostaglandins, Growth Factors, and Synthetic Chemoattractants, American Journal of Ophthalmology, vol. 86, No. 4, pp. 455-461, (1978).
Cantrill, et al., Comparison of In Vitro Potency of Corticosteroids with Ability to Raise Intraocular Pressure, Am. J. Opthal., vol.. 79, No. 6, pp. 1012-1016 (1975).
Cariou, et al., Inhibition of Human Endothelial Cell Proliferation by Heparin and Steroids, Cell Biology International Reports, vol. 12, No. 12, pp. 1037-1047 (Dec., 1988).
Cella, J.A., A Convenient Procedure For Preparative Scale Oxidation Of Enones, Synthetic Communications, vol. 13(2), pp. 93-98 (1983).
Clark, Steroids, Ocular Hypertension and Glaucoma, J. Glaucoma, vol. 4, pp. 354-369 (1995).
Crum, et al., A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment, Science, vol. 230, pp. 1375-1378 (1985).
Djerassi, et al., Selective Reduction Of Steroids by Homogeneous Catalytic Hydrogenation, J. Am. Chem. Soc., vol. 88, pp. 4537-4538 (1966).
Folkman, et al., Angiogenic Factors, Science, vol. 235, pp. 442-447 (1987).
Folkman, et al., Angiogstatic Steroids, Ann. Surg., vol. 206, No. 3, pp. 374-382 (1987).
Furcht, Critical Factors Controlling Angiogenesis: Cell Products, Cell Matrix, and Growth Factors, Laboratory Investigation, vol. 55, No. 5, pp. 505-509 (1986).
Ingber, et al., A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution, Endocrinology, vol. 119, No. 4, pp. 1768-1775 (1986).
Johnson, et al., Glaucoma: An Overview, Mayo Clin. Proc, vol. 61, pp. 59-67 (1986).
Kitazawa, Increased Intraocular Pressure Induced by Corticosteroids, American Journal Of Ophthalmology, vol. 82, No. 3, pp. 492-495 (1976).
Knepper, et al., Glycosaminoglycans and Outflow Pathways of the Eye and Brain, Pediatric Neuroscience, vol. 12, pp. 240-251 1986.
Li, et al., Angiostatic Steroids Potentiated by Sulphated Cyclodextrin Inhibit Corneal Neovascularization, Investigative Ophthalmology and Visual Science, vol. 32, No. 11, pp. 2898-2905 (1991).
Maragoudakis, et al., Antiangiogenic Action of Heparin Plus Cortisone is Associated with Decreased Collagenous Protein Synthesis in the Chick Chorioallantoic Membrane System, The Journal of Pharmacology and Experimental Therapeutics, vol. 251, No. 2, pp. 679-682 (1989).
Milewich, et al., Organic Syntheses, Collective vol. VI, p. 690 (1988).
Mindel, et al., Comparative Ocular Pressure Elevation by Medrysone, Fluorometholone, and Dexamethasone Phosphate, Arch. Ophthalmol., vol. 98, pp. 1577-1578 (1980).
Rohen, Why is Intraocular Pressure Elevated in Chronic Simple Galucoma?, American Academy of Ophthalmology, vol. 90, No. 7, pp. 758-765 (1983).
Southren, et al., Intraocular Hypotensive Effect of a Topically Applied Cortisol Metabolite, Tetrahydrocortisol, Investigative Ophthalmology and Visual Science, vol. 28 (May, 1987).
Takeda, et al., J. Am. Chem. Soc., vol. 105, pp. 563-568 (1983).
Tokida, et al., Production of Two Variant Laminin Forms by Endothelial Cells and Shift of Their Relative Levels by Angiostatic Steroids, The Journal of Biological Chemistry, vol. 264, No. 30, pp. 18123-18129 (1990).
Wieland, et al., Helvetica Chemica Acta, vol. 50, pp. 2108-2110 (1967).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

A-seco steroids effective at treating ophthalmic pathological ne does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with A-seco steroids effective at treating ophthalmic pathological ne, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A-seco steroids effective at treating ophthalmic pathological ne will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-879182

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.