A process for the preparation of anhydrous, stable, crystalline

Details A process for the preparation of anhydrous, stable, crystalline A process for the preparation of anhydrous, stable, crystalline

1988-02-08

1989-10-10

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

203 14, 203 67, 203 69, C07D40514

Patent

active

048733300

ABSTRACT:
Anhydrous, stable, crystalline .delta.-form of prazosin hydrochloride, having an infrared spectrum in potassium bromide of FIG. 1 having the following sharp absorption bands at 7.95.mu., 13.3.mu., and a triplet at 9.95.mu. and the x-ray diffractogram of FIG. 2 having sharp bands in 10.5.degree., 12.0.degree., 16.9.degree., and doublets in 24.5.degree. and 26.5.degree.. The .delta.-form of prazosin hydrochloride is prepared by removing the water of crystallization of prazosin hydrochloride hydrate by azeotropic distillation with selected organic solvents having a boiling point in the range of 55.degree.-160.degree. C. The .delta.-form of prazosin hydrochlorie is useful as a hypotensive agent.

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