A process for producing legionella specific antibiotic using Str

Details A process for producing legionella specific antibiotic using Str A process for producing legionella specific antibiotic using Str

1995-06-06

1996-04-02

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

4242341, 435135, 435886, 435147, 4352535, 514546, 514547, 514549, 514552, 554 1, A61K 3902, C12P 702, C12N 120

Patent

active

055039979

ABSTRACT:
A Legionella specific antibiotic AL072, a Streptomyces sp. AL91 producing the antibiotic, and a process for producing the antibiotic are disclosed. Further, the antibiotic compound has a specified formula. The formula is ##STR1## In addition the process also includes extraction of a culture broth provided by cultivating the microorganism Streptomyces sp. AL91, accession number KCCM 10055, with isopropyl alcohol and ethyl acetate to obtain an extract containing the antibiotic compound. The compound is then isolated from the extract by chromatography on a column filled with octadecyl silica gel and also by high pressure liquid chromatography.

REFERENCES:
patent: 4988677 (1991-01-01), Franco et al.
Goodman and Gilman's "The Pharmacological Basis of Therapeutics", 1990 edition, p. 1023.

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