A-form of cytoplasmic domain of nARIA (CRD-neuregulin) and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007200, C435S007920

Reexamination Certificate

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06933122

ABSTRACT:
This invention provides nARIA-based assays for defining whether a subject has or is predisposed to developing a neoplastic disease. This invention further provides a nARIA-based method for maintaining synaptic connections between a neuron and a target cell.

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McGehee, D.S. et al., (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors.Science269:1692-1696 (Exhibit 16).
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Vartanian, T. et al., (1994) A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development.PNAS, U.S.A.91:11626-11630 (Exhibit 19).
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Wolpowitz, D. et al., Isoform Specific Knockout of Neuregulin-1 gene products: Selective Disruption of Only Cysteine-Rich Domain (CRD) -containing Isoforms, Mouse Genetics Conference, Cold Spring Harbor (1998) (Exhibit 23).

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