A-deoxy-a-aza derivatives of clavulanic acid, a process for thei

Details A-deoxy-a-aza derivatives of clavulanic acid, a process for thei A-deoxy-a-aza derivatives of clavulanic acid, a process for thei

1983-04-13

1987-03-24

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

424114, 540348, C07D49804, A61K 3142

Patent

active

046525602

ABSTRACT:
The compounds of the formula (II): ##STR1## or pharmaceutically acceptable salts or esters thereof wherein A is a hydrogen atom or an esterifying radical; X is an alkyl group of 1-12 carbon atoms optionally substituted by a hydroxy, amino, acylamino of C.sub.1-6 alkoxy group, which substituents are not on the carbon atom adjacent to the nitrogen atom; or a C.sub.5-7 cycloalkyl group; or a phenylalkyl group wherein the carbon atom content of the alkyl part is 1-6 and the phenyl part is optionally substituted with a fluorine, bromine, chlorine, C.sub.1-6 alkyl, or C.sub.1-6 alkoxy; with the proviso that when X represents an optionally substituted phenylalkyl group and A represents C.sub.1-3 alkyl, then the --CO.sub.2 A group is attached to the alkyl part of the phenylalkyl group; have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use is described.

REFERENCES:
patent: 4093626 (1978-06-01), Hunt
patent: 4256638 (1981-03-01), Ponsford
patent: 4315006 (1982-02-01), Storer
patent: 4315935 (1982-02-01), Ali
patent: 4316907 (1982-02-01), Oxford et al.
patent: 4317826 (1982-03-01), Gleason
patent: 4317835 (1982-03-01), Van Dijk et al.
patent: 4321254 (1982-03-01), Ali
patent: 4341786 (1982-07-01), Demarinis et al.
patent: 4350685 (1982-09-01), Ali et al.
patent: 4351842 (1982-09-01), Coles
patent: 4352809 (1982-10-01), Bondinell et al.
patent: 4366167 (1982-12-01), Corbett
patent: 4379787 (1983-04-01), Lunn et al.
patent: 4382084 (1983-05-01), Ponsford et al.
patent: 4382932 (1983-05-01), Lunn et al.
patent: 4385047 (1983-05-01), Ali
patent: 4388316 (1983-06-01), Lunn et al.
patent: 4393072 (1983-07-01), Merkel et al.
patent: 4395406 (1983-07-01), Gacek et al.
patent: 4395421 (1983-07-01), Taylor et al.
patent: 4396619 (1983-08-01), Lunn et al.
patent: 4396620 (1983-08-01), Lunn
patent: 4397845 (1983-08-01), Allen
patent: 4399142 (1983-08-01), Durant et al.
patent: 4401665 (1983-08-01), Sheinaus et al.
patent: 4401668 (1983-08-01), Lunn
patent: 4402949 (1983-09-01), Hartmann et al.
patent: 4402955 (1983-09-01), Lunn
patent: 4402974 (1983-09-01), Matier et al.
patent: 4402976 (1983-09-01), Muir
patent: 4405596 (1983-09-01), Helbig et al.
patent: 4406898 (1983-09-01), Lunn et al.
patent: 4406899 (1983-09-01), Aburaki et al.
patent: 4411907 (1983-10-01), Toia
patent: 4411909 (1983-10-01), Gonella
patent: 4414204 (1983-11-01), Tarcsay et al.
patent: 4421760 (1983-12-01), Box
patent: 4427690 (1984-01-01), Cole et al.
patent: 4428958 (1984-01-01), Ponsford
patent: 4444754 (1984-04-01), Stirling et al.
patent: 4444783 (1984-04-01), Eglington
patent: 4446146 (1984-05-01), Southgate et al.
patent: 4524073 (1985-06-01), Stirling
Stirling et al. Chem. Abs. 90, 168574 (1978).
Ponsford et al. Chem. Abs. 87, 84978g (1977).
Cherry et al. Chem. Abs. 88, 6861v (1977).

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