A composition and a method of using veratridine and epinephrine

Details A composition and a method of using veratridine and epinephrine A composition and a method of using veratridine and epinephrine

1991-10-22

1994-02-22

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514652, 514653, 514818, 424 10, A61K 3144, A61K 31135, A61K 4900

Patent

active

052887235

ABSTRACT:
A method of using veratridine to inhibit nerve impulses, and a composition of matter including veratridine and epinephrine, is provided. Application of veratridine proximal to a nerve causes depolarization of the nerve membrane, thereby blocking transmission of nerve impules. C-fiber selectivity is demonstrated in vitro in rabbit vagus nerves. Veratridine displays extended anesthetic activity over long periods of time when compared to similar local anesthetics, with no local toxicity. Systemic toxicity is reduced by co-injection with epinephrine.

REFERENCES:
Chemical Abstracts (114: 199510s) 1991.
The Merck Index "Epinephrine 3543" 9th Ed. 1983.
Ganong, W. F., Review of Medical Physiology, 9th ed., Chapter 2, pp. 29-34, Lange Medical Pub., Los Altos, Calif. (1979).
Windholz, M., et al. (eds), The Merck Index, (10th ed), p. 1422, Merck & Co., Inc., Rahway, N.J. (1983).
Goodman and Gilman (eds), The Pharmacological Basis of Therapeutics, 8th ed., Chapter 15, pp. 311-331, Pergamon Press, N.Y. (1990).
Schneider, M., et al., Anesthesiology 73:3A:A790 (1990).
Schneider, M., et al., Anesthesiology 74:270-280 (1991).
Strichartz, G. R., et al., Anesthesiology 75:3A:A771 (1991).
Hunt, et al., In Vitro and In Vivo Action of Veratridine on the Rat Sciatic Nerve, poster presentation at Oct. 29, 1991 Annual Meeting of the American Society of Anesthesiologists, San Francisco, Calif.

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