A-C-B proinsulin, method of manufacturing and using same, and in

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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43525233, 530303, 530350, 536 2351, 514 3, C12P 1934, C12N 120, A61K 3702, C07K 500

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053044738

ABSTRACT:
The instant invention provides novel molecules derived from the components of proinsulin using recombinant DNA technology. The invention provides molecules of the formula A--C--B wherein A is the A-chain of an insulin species, B is the B-chain of an insulin species and C is a connecting peptide. These molecules possess insulin-like activity and are useful for the treatment of diabetes mellitus, particularly non-insulin dependent diabetes mellitus. These molecules are also useful for the production of insulin and constitute a novel pathway for the recombinant production of insulin species. The invention provides a method of making insulin proceeding through the compounds of the invention as intermediates. The instant invention further provides recombinant DNA compounds which encode the compounds of the invention.

REFERENCES:
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Peavy et al. J.B.C. 260:13989-13994 1990.
Bayne et al., Gene 66:235-244 1988.
Lin et al. (1975) Biochemistry USA 14:1559-1563.
Burgess et al. (1990) J. Cell. Biol. 111:2129-2138.
Lazar et al. (1988) Mol. and Cell. Biol. 8:1247-1252.

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