Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1991-06-11
1994-04-19
Lacey, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
43525233, 530303, 530350, 536 2351, 514 3, C12P 1934, C12N 120, A61K 3702, C07K 500
Patent
active
053044738
ABSTRACT:
The instant invention provides novel molecules derived from the components of proinsulin using recombinant DNA technology. The invention provides molecules of the formula A--C--B wherein A is the A-chain of an insulin species, B is the B-chain of an insulin species and C is a connecting peptide. These molecules possess insulin-like activity and are useful for the treatment of diabetes mellitus, particularly non-insulin dependent diabetes mellitus. These molecules are also useful for the production of insulin and constitute a novel pathway for the recombinant production of insulin species. The invention provides a method of making insulin proceeding through the compounds of the invention as intermediates. The instant invention further provides recombinant DNA compounds which encode the compounds of the invention.
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Bayne et al., Gene 66:235-244 1988.
Lin et al. (1975) Biochemistry USA 14:1559-1563.
Burgess et al. (1990) J. Cell. Biol. 111:2129-2138.
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Belagaje Rama M.
DiMarchi Richard D.
Heath, Jr. William F.
Long Harlan B.
Adams Donald E.
Eli Lilly and Company
Lacey David L.
Murphy Richard B.
Whitaker Leroy
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