Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1993-12-21
2000-08-29
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530322, C07K 750, C07K 900
Patent
active
061110671
ABSTRACT:
A82846-related glycopeptide compounds are prepared by treating an antibiotic selected from A82846 components A, B and C with trifluoroacetic acid to remove 1) the .alpha.-L-O-4-epi-vancosaminyl group attached to the disaccharide; 2) the (.alpha.-L-O-4-epi-vancosaminyl-.beta.-O-glucosyl) disaccharide group or 3) both the disaccharide group and the .alpha.-L-O-4-epi-vancosaminyl group attached to the peptide core from these antibiotics. The compounds have antibacterial activity, especially against Gram-positive microorganisms.
REFERENCES:
patent: 4029769 (1977-06-01), Debono
patent: 4322343 (1982-03-01), Debono
patent: 4552701 (1985-11-01), Nagarajan et al.
patent: 5071749 (1991-12-01), Kondo et al.
EPO published application 0265071 (Apr. 27, 1988), p. 1-5 of application.
Debono Manuel
Molloy R. Michael
Nagarajan Ramakrishnan
Schabel Amelia A.
Eli Lilly and Company
Musser Arlene K.
Plant Thomas G.
Russel Jeffrey E.
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