A-40104 Antibiotics and process for production thereof

Details A-40104 Antibiotics and process for production thereof A-40104 Antibiotics and process for production thereof

1978-06-22

1981-01-27

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435171, A61K 3500

Patent

active

042475422

ABSTRACT:
A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.

REFERENCES:
Knauseder et al., J. Antibiotics 29, pp. 125-131 (1976).
Kavanagh et al., Proc. Natl. Acad. Sci., 38, pp. 555-560 (1952).

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