Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing at least three carbocyclic rings
Patent
1981-02-09
1983-10-18
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing at least three carbocyclic rings
435172, 435886, C12P 1500, C12N 1500, C12R 1465
Patent
active
044106289
ABSTRACT:
Antibiotic A-39183 complex, comprising microbiologically active, related factors A, B, C, D, and E, is produced by submerged, aerobic fermentation of a new microorganism Streptomyces sp., NRRL 12049. The A-39183 antibiotics are closely related antibiotics. The individual A-39183 factors are separated by chromatography. The A-39183 factors are antibacterial agents which have activity against Staphylococcus and Streptococcus species that are penicillin resistant. The A-39183 factors are also active against both gram-positive and gram-negative anaerobic bacteria, and are ionophores.
REFERENCES:
patent: 3769418 (1973-10-01), Prelog et al.
Omura et al., The Journal of Antibiotics, vol. 31, pp. 1091-1098 (1978).
R. Hutter et al., Helv. Chim. Act. 50, 1533-1539 (1967).
J. D. Dunitz et al., Helv. Chim. Act. 54, 1709-1713 (1971).
"Structure and Biosynthesis of Setomimycin. A Novel 9,9'-Beanthryl Antibiotic", Kakinuma et al., J. Am. Chem. Soc. 102, 7493-7498 (1980).
Derwent Farmdoc, Abstracting Japan Pat. No. 76154B/42, Published 2-28-78.
Kastner Ralph E.
Koch Kay F.
Eli Lilly and Company
Scanon William B.
Tanenholtz Alvin E.
Whale Arthur R.
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