A-30912D Nucleus

Details A-30912D Nucleus A-30912D Nucleus

1980-08-25

1981-11-10

Phillips, Delbert K.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 435 71, A61K 3700, C07C10352, C12P 2104

Patent

active

042997623

ABSTRACT:
A-30912D nucleus, which is prepared by enzymatic deacylation of an antibiotic selected from A-30912 factor D and tetrahydro-A-30912D using an enzyme produced by the Actinoplanaceae, preferably by Actinoplanes utahensis. A-30912D nucleus and salts thereof are useful intermediates to prepare new semi-synthetic antifungal agents.

REFERENCES:
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patent: 3978210 (1976-08-01), Mizuno et al.
patent: 4024245 (1977-05-01), Hoehn et al.
patent: 4024246 (1977-05-01), Higgens et al.
patent: 4050989 (1977-09-01), Kuwana et al.
patent: 4173629 (1979-11-01), Dreyfuss et al.
T. Kato, et al., J. Antibiotics 29 (12) 1339-1340, (1976).
S. Chihara et al., Agr. Biol. Chem. 37 (11), 2455-2463, (1973).
Ibid. 37 (12), 2709-2717 (1973).
Ibid. 38 (3), 521-529, (1974).
Ibid. 38 (10), 1767-1777, (1974).
T. Suzuki, et al., J. Biochem. 56 (4), 335-343, (1964).
J. M. Weber, et al., J. Antibiotics 31 (4), 373-374, (1978).
J. Shoji, et al., J. Antibiotics 28, 764-769, (1975).
Ibid. 29 (4), 380-389, (1976).
Ibid. (12) 1268-1274, (1976).
Ibid. (12) 1275-1280 (1976).
F. Benz, et al. Helv. Chim. Acta. 57, 2459, (1974).
C. Keller-JuSlen, et al., Tetrahedron Letters 4147-4150, 1976, vol. 46.
R. Traber, et al., Helv. Chim. Acta. 62, 1252, (1979).

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