A-30912B Nucleus

Details A-30912B Nucleus A-30912B Nucleus

1980-08-25

1981-11-10

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 435 71, C07C10352, A61K 3700, C12P 2104

Patent

active

042997631

ABSTRACT:
A-30912B nucleus, which is prepared by enzymatic deacylation of an antibiotic selected from A-30912 factor B and tetrahydro-A-30912B using an enzyme produced by the Actinoplanaceae, preferably by Actinoplanes utahensis. A-30912B nucleus and salts thereof are useful intermediates to prepare new semisynthetic antifungal agents.

REFERENCES:
patent: 3150059 (1964-09-01), Kleinschmidt et al.
patent: 3978210 (1976-08-01), Mizuno et al.
patent: 4024245 (1977-05-01), Hoehn et al.
patent: 4024246 (1977-05-01), Higgens et al.
patent: 4050989 (1977-09-01), Kuwana et al.
patent: 4173629 (1979-11-01), Dreyfuss et al.
T. Kato et al., J. Antibiotics 29(12), 1339-1340, (1976).
S. Chihara et al., Agr. Biol. Chem. 37(11), 2455-2463, (1973).
Ibid. 37(12), 2709-2717, (1973).
Ibid. 38(3), 521-529, (1974).
Ibid. 38(10), 1767-1777, (1974).
T. Suzuki et al., J. Biochem. 56(4), 335-343, (1964).
J. M. Weber et al., J. Antibiotics 31(4), 373-374, (1978).
J. Shoji et al., J. Antibiotics 28, 764-769, (1975).
Ibid. 29(4), 380-389, (1976).
Ibid. (12), 1268-1274 (1976).
Ibid. (12). 1275-1280, (1976).
F. Benz et al., Helv. Chim. Acta 57, 2459, (1974).
C. Keller-JuSlen et al., Tetrahedron Letters, 4147-4150, 1976, vol. 46.
R. Traber et al., Helv. Chim. Acta 62, 1252, (1979).

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