A-30912A Nucleus

Details A-30912A Nucleus A-30912A Nucleus

1980-08-25

1981-10-06

Philips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 435 71, C07C10352, H61K 3700, C12P 2104

Patent

active

042934826

ABSTRACT:
A-30912A nucleus, which is prepared by enzymatic deacylation of an antibiotic selected from A-30912 factor A, tetrahydro-A-30912A, and aculeacin A using an enzyme produced by the Actinoplanaceae, preferably by Actinoplanes utahensis. A-30912A nucleus and salts thereof are useful intermediates to prepare new semi-synthetic antifungal agents.

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T. Suzuki et al., J. Biochem. 56 (4), 335-343 (1964).
J. M. Weber et al., J. Antibiotics 31 (4), 373-374 (1978).
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J. Shoji et al., Ibid. 29 (4), 380-389 (1976).
J. Shoji et al., Ibid. (12), 1268-1274 (1976).
J. Shoji et al., Ibid. (12), 1275-1280 (1976).
F. Benz et al., Heln, Chim. Acta. 57, 2459 (1974).
C. Keller-Juslen, et al., Tetrahedron Letters, 4147-4150, 1976, vol. 46.
R. Traber et al., Helv. Chim. Acta. 62, 1252 (1979).

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