A 2B adenosine receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S263380, C514S263370, C544S276000, C544S277000

Reexamination Certificate

active

10837290

ABSTRACT:
Disclosed are novel A2Badenosine receptor antagonists of Formula I:A compound of the formula:wherein:R1is optionally substituted alkyl or a group —Y-Z, in which Y is a covalent bond or optionally substituted alkylene, and Z is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkenyl or optionally substituted alkynyl, with the proviso that when Y is a covalent bond Z cannot be alkenyl or alkynyl; andX is oxygen, sulfur, or NH—,or a pharmaceutically acceptable salt, ester, or prodrug thereof. The compounds are particularly useful for treating asthma and diabetic retinopathy.

REFERENCES:
patent: 2003/0149060 (2003-08-01), Cristalli
patent: 2004/0048868 (2004-03-01), Edwards et al.
patent: 2004/0204428 (2004-10-01), Giorgio et al.

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