A 2A adenosine receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S264000, C544S276000, C544S277000, C514S263370, C514S263380, C514S263400, C514S263230

Reexamination Certificate

active

10322985

ABSTRACT:
Disclosed are novel A2Aadenosine receptor antagonists of the formula:wherein:R1is optionally substituted aryl or optionally substituted heteroaryl;R2is optionally substituted lower alkyl or optionally substituted cycloalkyl;R3is hydrogen, halogen, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl;X is —O—, —S—, or —NH—; andY is optionally substituted alkylene;and the pharmaceutically acceptable salts thereof;which are useful for treating various disease states, for example cardiovascular disorders, including tissue damage due to ischemia, CNS diseases, including Parkinson's disease, depression, and the like.

REFERENCES:
patent: 5300509 (1994-04-01), Block et al.
patent: 5500428 (1996-03-01), Block et al.
patent: 6841549 (2005-01-01), Asano et al.
patent: 2003/0064999 (2003-04-01), Palle et al.
patent: 2004/0132748 (2004-07-01), Isobe et al.
patent: 2004/0204428 (2004-10-01), Giorgio et al.
patent: 1035123 (2000-09-01), None
patent: WO 9805335 (1998-02-01), None
patent: WO 0044750 (2000-08-01), None
patent: WO 01/49688 (2001-07-01), None
Chen J et al: “A Novel and Efficient Route to Chiral 2-Substituted Carbocyclic 5′-N-Ethyl-Carboxamido-Adenosine (C-Neca)”, Tetrahedron Elsevier Science Publishers, Amsterdam, NL, vol. 30, No. 41, 1989, pp. 5543-5546, XP002014505, ISSN: 0040-4020, table 1 and p. 5545, formulae 3, 4.
K.J.M. Andrews et al: “Experiments on the Synthesis of Purine Nucleosides.”, Journal of the Chemical Society, 1949, pp. 2490-2497, XP002236533, Letchworth GB, p. 2491, formula (II); pp. 2495-2496.

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