A-21978 Antibiotics and process for their production

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

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435 71, 435886, C12D 914, C07C10352, A61K 3700

Patent

active

RE0323330

ABSTRACT:
Antibiotic A-21978 complexes, in particular the A-21978C complex, comprising microbiologically active, related factors C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosporus NRRL 11379. The individual A-29178C factors are separated and isolated by chromatography. The A-21978 and A-21978C complexes; the A-21978C factors; and pharmaceutically acceptable salts thereof are antibacterial agents and improve growth promotion in poultry.

REFERENCES:
J. Shoji, et al., "The Total Structure of Cerexin A", Journal of Antibiotics, 29 (12) 1268-1274 (1976).
J. Shoji, et al., "The Structure of Cerexin B", ibid., 29 (12) 1275-1280 (1976).
J. Shoji, et al., "The Structure of Brevistin", ibid., 29 (4) 380-389 (1976).

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