A-21978 antibiotics and process for their production

Details A-21978 antibiotics and process for their production A-21978 antibiotics and process for their production

1985-09-26

1987-07-07

Ore, Dale R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

424115, 435117, 530300, 530318, 530320, C07C10352

Patent

active

RE0324558

ABSTRACT:
Antibiotic A-21978C complexes, in particular the A-21978C complex, comprising microbiologically active, related factors, C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosporus NRRL 11379. The individual A-21978C factors are separated and isolated by chromatography. The A-21978 and A-21978C complexes, the A-21978C factors, and pharmaceutically acceptable salts thereof are antibacterial agents and improve growth promotion in poultry.

REFERENCES:
J. Shoji, et al., "The Total Structure of Cerexin A", Journal of Antibiotics, 29 (12) 1268-1274 (1976).
J. Shoji, et al., "The Structure of Cerexin B", Ibid., 29 (12) 1275-1280 (1976).
J. Shoji, et al., "The Structure of Brevistin", Ibid., 29 (4) 380-389 (1976).

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